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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1993-2-1
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pubmed:abstractText |
Desalaninebenanomicin A has been synthesized in good yield by the cleavage of the amido bond of benanomicin A using MEERWEIN's reagent. This is a useful intermediate to prepare amino acid analogs of benanomicin A. MEERWEIN's reagent reacts with totally protected benanomicin A to give a stable imino ether. After deprotection, the imino ether is treated with aqueous acetone at reflux to afford a methyl ester of desalaninebenanomicin A. Desalaninebenanomicin A was coupled with a variety of amino acids by the active ester method to afford new benanomicin analogs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1645-52
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1473992-Amino Acids,
pubmed-meshheading:1473992-Anthracyclines,
pubmed-meshheading:1473992-Antibiotics, Antineoplastic,
pubmed-meshheading:1473992-Antifungal Agents,
pubmed-meshheading:1473992-Fungi,
pubmed-meshheading:1473992-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1473992-Microbial Sensitivity Tests,
pubmed-meshheading:1473992-Naphthacenes,
pubmed-meshheading:1473992-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:1473992-Structure-Activity Relationship
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pubmed:year |
1992
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pubmed:articleTitle |
Amino acid analogs of benanomicin A through desalaninebenanomicin A.
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pubmed:affiliation |
Institute of Microbial Chemistry, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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