rdf:type |
|
lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0014644,
umls-concept:C0017262,
umls-concept:C0028587,
umls-concept:C0041904,
umls-concept:C0185117,
umls-concept:C0206243,
umls-concept:C0220756,
umls-concept:C0238301,
umls-concept:C0598988,
umls-concept:C1334346,
umls-concept:C1427812,
umls-concept:C1512474,
umls-concept:C2266853,
umls-concept:C2911684
|
pubmed:issue |
1
|
pubmed:dateCreated |
2004-1-23
|
pubmed:abstractText |
In about 60% of Epstein-Barr virus (EBV) carrying nasopharyngeal carcinomas (NPC) LMP1 expressing cells can be detected. The frequency of LMP1 positive cells and the expression level varies from cell to cell in the different tumors. Cell lines derived from EBV positive NPCs loose the virus during in vitro culture. The in vitro infected NPC cell line TWO3-EBV used in our study carries the neomycin-resistance gene containing EBV and expresses low level of LMP1. With this cell line it was thus possible to study the regulation of LMP1 expression by modification of chromatin acetylation state.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0920-8569
|
pubmed:author |
pubmed-author:BandobashiKentaroK,
pubmed-author:KisLorand LLL,
pubmed-author:KissCsabaC,
pubmed-author:KleinEvaE,
pubmed-author:KleinGeorgeG,
pubmed-author:LiuAnquanA,
pubmed-author:NagyNoemiN,
pubmed-author:NishikawaJunJ,
pubmed-author:OkitaKiwamuK,
pubmed-author:TakaharaMikiM,
pubmed-author:ZhangXiangningX
|
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
121-8
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:14739656-Acetylation,
pubmed-meshheading:14739656-Butyrates,
pubmed-meshheading:14739656-Carcinoma,
pubmed-meshheading:14739656-DNA,
pubmed-meshheading:14739656-Gene Expression Regulation, Viral,
pubmed-meshheading:14739656-Herpesvirus 4, Human,
pubmed-meshheading:14739656-Histone Deacetylase Inhibitors,
pubmed-meshheading:14739656-Humans,
pubmed-meshheading:14739656-Hydroxamic Acids,
pubmed-meshheading:14739656-Nasopharyngeal Neoplasms,
pubmed-meshheading:14739656-Promoter Regions, Genetic,
pubmed-meshheading:14739656-RNA, Messenger,
pubmed-meshheading:14739656-Up-Regulation,
pubmed-meshheading:14739656-Viral Matrix Proteins
|
pubmed:year |
2004
|
pubmed:articleTitle |
Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line.
|
pubmed:affiliation |
Microbiology and Tumor Biology Center, Karolinska Institute, S-171 77 Stockholm, Sweden.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|