Source:http://linkedlifedata.com/resource/pubmed/id/14739366
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2004-3-22
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pubmed:abstractText |
Neurofibromatosis type one (NF1) is a common genetic disorder affecting 1:4000 births and is characterized by benign and malignant tumors. Children with NF1 are predisposed to juvenile myelomonocytic leukemia. The Nf1 gene encodes neurofibromin, which can function as a Ras GTPase-activating protein. Neurofibromin deficiency in mice leads to mid-gestation lethality due to cardiovascular defects. We have previously shown that conditional inactivation of Nf1 using Tie2-Cre recapitulates the heart defects seen in Nf1(-/-) embryos. Tie2-Cre transgenic mice express Cre recombinase in all endothelial cells. Here, we show that Tie2-Cre-mediated deletion of Nf1 also leads to excision of Nf1 in the hematopoietic lineage. Surviving mice exhibit a myeloproliferative disorder similar to juvenile myelomonocytic leukemia seen in NF1 patients. These mice provide a useful model to study neurofibromin deficiency in hematopoiesis. Furthermore, defects in Tie2-Cre-expressing progenitors that result in heart and blood defects suggest that related heart and blood disorders in NF1 and other syndromes represent disorders of the hemangioblast.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0031-3998
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14739366-Alleles,
pubmed-meshheading:14739366-Animals,
pubmed-meshheading:14739366-Child,
pubmed-meshheading:14739366-Disease Models, Animal,
pubmed-meshheading:14739366-Gene Silencing,
pubmed-meshheading:14739366-Genes, Neurofibromatosis 1,
pubmed-meshheading:14739366-Hematopoietic Stem Cells,
pubmed-meshheading:14739366-Humans,
pubmed-meshheading:14739366-Integrases,
pubmed-meshheading:14739366-Leukemia, Myelomonocytic, Chronic,
pubmed-meshheading:14739366-Leukocytes,
pubmed-meshheading:14739366-Mice,
pubmed-meshheading:14739366-Mice, Transgenic,
pubmed-meshheading:14739366-Myeloproliferative Disorders,
pubmed-meshheading:14739366-Receptor, TIE-2,
pubmed-meshheading:14739366-Spleen
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pubmed:year |
2004
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pubmed:articleTitle |
Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia.
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pubmed:affiliation |
Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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