Source:http://linkedlifedata.com/resource/pubmed/id/14739162
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2004-3-19
|
| pubmed:abstractText |
Several endothelial growth factors induce both blood and lymphatic angiogenesis. However, a systematic comparative study of the impact of these factors on vascular morphology and function has been lacking. In this study, we report a quantitative analysis of the structure and macromolecular permeability of FGF-2-, VEGF-A-, and VEGF-C-induced blood and lymphatic vessels. Our results show that VEGF-A stimulated formation of disorganized, nascent vasculatures as a result of fusion of blood capillaries into premature plexuses with only a few lymphatic vessels. Ultrastructural analysis revealed that VEGF-A-induced blood vessels contained high numbers of endothelial fenestrations that mediated high permeability to ferritin, whereas the FGF-2-induced blood vessels lacked vascular fenestrations and showed only little leakage of ferritin. VEGF-C induced approximately equal amounts of blood and lymphatic capillaries with endothelial fenestrations present only on blood capillaries, mediating a medium level of ferritin leakage into the perivascular space. No endothelial fenestrations were found in FGF-2-, VEGF-A-, or VEGF-C-induced lymphatic vessels. These findings highlight the structural and functional differences between blood and lymphatic vessels induced by FGF-2, VEGF-A, and VEGF-C. Such information is important to consider in development of novel therapeutic strategies using these angiogenic factors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor C
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
1524-4571
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
19
|
| pubmed:volume |
94
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
664-70
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| pubmed:dateRevised |
2007-5-2
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| pubmed:meshHeading |
pubmed-meshheading:14739162-Animals,
pubmed-meshheading:14739162-Capillaries,
pubmed-meshheading:14739162-Capillary Permeability,
pubmed-meshheading:14739162-Caveolae,
pubmed-meshheading:14739162-Corneal Neovascularization,
pubmed-meshheading:14739162-Drug Implants,
pubmed-meshheading:14739162-Endothelium, Vascular,
pubmed-meshheading:14739162-Ferritins,
pubmed-meshheading:14739162-Fibroblast Growth Factor 2,
pubmed-meshheading:14739162-Humans,
pubmed-meshheading:14739162-Image Processing, Computer-Assisted,
pubmed-meshheading:14739162-Lymphangiogenesis,
pubmed-meshheading:14739162-Male,
pubmed-meshheading:14739162-Mice,
pubmed-meshheading:14739162-Mice, Inbred C57BL,
pubmed-meshheading:14739162-Recombinant Fusion Proteins,
pubmed-meshheading:14739162-Vascular Endothelial Growth Factor A,
pubmed-meshheading:14739162-Vascular Endothelial Growth Factor C
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability.
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| pubmed:affiliation |
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|