Source:http://linkedlifedata.com/resource/pubmed/id/14738889
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-1-23
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pubmed:abstractText |
Since the 1970s, cytomegalovirus (CMV) infection has been associated with atherosclerotic disease. However, the exact contribution of the virus remains uncertain. In this article we describe both a direct and indirect immune-mediated effect of the virus on the disease process. Eight-week-old apolipoprotein E (apoE) knockout mice were infected with mouse CMV (MCMV) or mock injected, and they were sacrificed at 2 and 20 weeks post-injection (p.i.) to study atherosclerosis, vascular wall IFNgamma and TNFalpha expression and MCMV spread. To study plasma IFNgamma and TNFalpha levels, blood was collected at 1, 2, 4 and 6 days p.i. in addition to days of sacrifice. Plasma cytokine levels were increased after MCMV infection at early time points and decreased to mock levels at 2 and 20 weeks p.i. At 2 weeks p.i., more aortic arch samples showed local cytokine expression after MCMV infection. The number of early atherosclerotic lesions and the percentage of mice containing early lesions were increased at 2 weeks p.i., while at 20 weeks p.i., the MCMV-induced effect on atherogenesis was seen on the late lesions. In conclusion, MCMV infection induces a systemic immune response reflecting an indirect effect of MCMV infection on atherosclerosis in addition to a local aortic immune response reflecting a direct effect of the virus on the atherosclerotic process.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1286-4579
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-24
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14738889-Animals,
pubmed-meshheading:14738889-Aorta, Thoracic,
pubmed-meshheading:14738889-Apolipoproteins E,
pubmed-meshheading:14738889-Arteriosclerosis,
pubmed-meshheading:14738889-Cytomegalovirus Infections,
pubmed-meshheading:14738889-Disease Models, Animal,
pubmed-meshheading:14738889-Immunocompetence,
pubmed-meshheading:14738889-Interferon-gamma,
pubmed-meshheading:14738889-Lung,
pubmed-meshheading:14738889-Mice,
pubmed-meshheading:14738889-Mice, Inbred C57BL,
pubmed-meshheading:14738889-Mice, Knockout,
pubmed-meshheading:14738889-Muromegalovirus,
pubmed-meshheading:14738889-Salivary Glands,
pubmed-meshheading:14738889-Spleen,
pubmed-meshheading:14738889-Time Factors,
pubmed-meshheading:14738889-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Cytomegalovirus infection aggravates atherogenesis in apoE knockout mice by both local and systemic immune activation.
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pubmed:affiliation |
Department of Medical Microbiology, University Hospital Maastricht, P. Debyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. ivl@lmib.azm.nl
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pubmed:publicationType |
Journal Article,
Comparative Study
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