Linked Life Data

14736850

Source:http://linkedlifedata.com/resource/pubmed/id/14736850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-1-22
pubmed:abstractText
Inflammatory pain is caused by sensitization of peripheral and central nociceptive neurons. Prostaglandins substantially contribute to neuronal sensitization at both sites. Prostaglandin E2 (PGE2) applied to the spinal cord causes neuronal hyperexcitability similar to peripheral inflammation. Because PGE2 can act through EP1-EP4 receptors, we addressed the role of these receptors in the spinal cord on the development of spinal hyperexcitability. Recordings were made from nociceptive dorsal horn neurons with main input from the knee joint, and responses of the neurons to noxious and innocuous stimulation of the knee, ankle, and paw were studied after spinal application of recently developed specific EP1-EP4 receptor agonists. Under normal conditions, spinal application of agonists at EP1, EP2, and EP4 receptors induced spinal hyperexcitability similar to PGE2. Interestingly, the effect of spinal EP receptor activation changed during joint inflammation. When the knee joint had been inflamed 7-11 hr before the recordings, only activation of the EP1 receptor caused additional facilitation, whereas spinal application of EP2 and EP4 receptor agonists had no effect. Additionally, an EP3alpha receptor agonist reduced responses to mechanical stimulation. The latter also attenuated spinal hyperexcitability induced by spinal PGE2. In isolated DRG neurons, the EP3alpha agonist reduced the facilitatory effect of PGE2 on TTX-resistant sodium currents. Thus pronociceptive effects of spinal PGE2 can be limited, particularly under inflammatory conditions, through activation of an inhibitory splice variant of the EP3 receptor. The latter might be an interesting target for controlling spinal hyperexcitability in inflammatory pain states.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
642-51
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:14736850-Animals, pubmed-meshheading:14736850-Arthritis, pubmed-meshheading:14736850-Carrageenan, pubmed-meshheading:14736850-Cell Separation, pubmed-meshheading:14736850-Dinoprostone, pubmed-meshheading:14736850-Disease Models, Animal, pubmed-meshheading:14736850-Ganglia, Spinal, pubmed-meshheading:14736850-Kaolin, pubmed-meshheading:14736850-Knee Joint, pubmed-meshheading:14736850-Male, pubmed-meshheading:14736850-Neurons, pubmed-meshheading:14736850-Pain, pubmed-meshheading:14736850-Patch-Clamp Techniques, pubmed-meshheading:14736850-Physical Stimulation, pubmed-meshheading:14736850-Protein Isoforms, pubmed-meshheading:14736850-Rats, pubmed-meshheading:14736850-Rats, Wistar, pubmed-meshheading:14736850-Receptors, Prostaglandin E, pubmed-meshheading:14736850-Receptors, Prostaglandin E, EP3 Subtype, pubmed-meshheading:14736850-Spinal Cord
pubmed:year
2004
pubmed:articleTitle
Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint.
pubmed:affiliation
Department of Physiology I, University of Jena, D-07740 Jena, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't