|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-1-21
|
|
pubmed:abstractText |
Serum and tissue levels of interleukin-6 (IL-6) have been implicated in the biological phenotype of breast carcinoma. A common G/C polymorphism at position -174 of the IL-6 promoter can influence the expression level of this gene. We therefore investigated for associations between this polymorphism and various phenotypic features in a series of 256 breast cancers. Individuals who were homozygous for the C allele (n=55) were more likely to have higher-grade tumours (P=0.039) with ductal histology (P=0.030) compared to those harbouring at least one wild-type G allele (n=201). Homozygosity for the C allele was also associated with significantly worse overall survival (P=0.031). We conclude that the -174 C allele of IL-6 is associated with a more aggressive breast cancer phenotype.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10365118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10408869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10657556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10747905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10761792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10813718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10848780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-10868978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-11872638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-11922913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12220549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12394188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12679452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12771987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12796383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12810629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12839942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-12919773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-2014824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-7538483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-8253529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-8674070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-9421363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-9516926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14735187-9769329
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0007-0920
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
90
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
419-22
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:14735187-Adolescent,
pubmed-meshheading:14735187-Adult,
pubmed-meshheading:14735187-Aged,
pubmed-meshheading:14735187-Aged, 80 and over,
pubmed-meshheading:14735187-Breast Neoplasms,
pubmed-meshheading:14735187-DNA, Neoplasm,
pubmed-meshheading:14735187-Female,
pubmed-meshheading:14735187-Humans,
pubmed-meshheading:14735187-Interleukin-6,
pubmed-meshheading:14735187-Middle Aged,
pubmed-meshheading:14735187-Phenotype,
pubmed-meshheading:14735187-Polymorphism, Genetic,
pubmed-meshheading:14735187-Prognosis,
pubmed-meshheading:14735187-Survival Analysis
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
The -174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype.
|
|
pubmed:affiliation |
School of Surgery and Pathology, University of Western Australia, Nedlands 6009, Australia. bijac@cyllene.uwa.edu.au
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
