Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2004-1-21
pubmed:abstractText
Many human inflammatory diseases are associated with tissue deposition of immune complexes and influx of neutrophils. We show that immune complexes bind preferentially to apoptotic neutrophils via FcgammaRIIA (CD32) and that increased binding is associated with clustering of immune complexes on the plasma membrane of the apoptotic cell. Phagocytosis of immune complex-opsonized apoptotic neutrophils by human macrophages was substantially enhanced (4.4-fold increase compared with control apoptotic neutrophils) and stimulated macrophages to release the proinflammatory cytokines TNF-alpha and IL-6. Immune complexes may perturb the normal pathways for clearance of apoptotic neutrophils by augmenting their clearance at the price of proinflammatory cytokine release. This represents a novel mechanism by which immune complexes may modulate the resolution of inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1882-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:14734773-Animals, pubmed-meshheading:14734773-Antigen-Antibody Complex, pubmed-meshheading:14734773-Antigens, CD, pubmed-meshheading:14734773-Apoptosis, pubmed-meshheading:14734773-Binding Sites, Antibody, pubmed-meshheading:14734773-Cytokines, pubmed-meshheading:14734773-Humans, pubmed-meshheading:14734773-Immunoglobulin G, pubmed-meshheading:14734773-Inflammation, pubmed-meshheading:14734773-Interleukin-6, pubmed-meshheading:14734773-Macrophages, pubmed-meshheading:14734773-Mice, pubmed-meshheading:14734773-Neutrophils, pubmed-meshheading:14734773-Opsonin Proteins, pubmed-meshheading:14734773-Phagocytosis, pubmed-meshheading:14734773-Protein Binding, pubmed-meshheading:14734773-Receptors, IgG, pubmed-meshheading:14734773-Serum Albumin, Bovine, pubmed-meshheading:14734773-Tumor Necrosis Factor-alpha, pubmed-meshheading:14734773-Up-Regulation
pubmed:year
2004
pubmed:articleTitle
Immune complexes bind preferentially to Fc gamma RIIA (CD32) on apoptotic neutrophils, leading to augmented phagocytosis by macrophages and release of proinflammatory cytokines.
pubmed:affiliation
Medical Research Council Center for Inflammation Research, University of Edinburgh Medical School, Edinburgh, United Kingdom. s.hart@ed.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't