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rdf:type |
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lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0031437,
umls-concept:C0035820,
umls-concept:C0036576,
umls-concept:C0039194,
umls-concept:C0042769,
umls-concept:C0085358,
umls-concept:C0205148,
umls-concept:C0205191,
umls-concept:C0439662,
umls-concept:C0851285,
umls-concept:C1280500,
umls-concept:C1327413,
umls-concept:C1332717,
umls-concept:C1334197,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
3
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pubmed:dateCreated |
2004-1-21
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pubmed:abstractText |
Regulation of CD8 T cell responses in chronic viral infections is not well understood. In this study, we have compared the CD8 T cell responses to immunodominant and subdominant epitopes during an acute and a chronic lymphocytic choriomeningitis virus (LCMV) infection in mice. The epitope hierarchy of the primary CD8 T cell response was similar in acute and chronic LCMV infections. However, strikingly, the epitope hierarchy of the primary CD8 T cell response was conserved in the T cell memory only in an acute but not in a chronic LCMV infection. Interestingly, in an acute infection, increasing the viral dose caused significant changes in the epitope hierarchy of the LCMV-specific memory CD8 T cell pool, with no effect on the primary CD8 T cell response. Functional and phenotypic analyses revealed that exposure of CD8 T cells to extended periods of antigenic stimulation could lead to long-term defects in cytokine production and alteration in expression of cell surface L-selectin (CD62L). Whereas expression of CD44 was minimally altered, a greater proportion of LCMV-specific memory CD8 T cells were CD62L(low) in mice that have recovered from a chronic LCMV infection, compared with acutely infected mice. Mechanistic studies showed that IFN-gammaR deficiency altered the epitope hierarchy of the pool of LCMV-specific memory CD8 T cells without significantly affecting the immunodominance of the primary CD8 T cell response in an acute infection. Taken together, these findings should further our understanding about the regulation of T cell responses in human chronic viral infections.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-6,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor,
http://linkedlifedata.com/resource/pubmed/chemical/proto-oncogene protein bcl-3
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1491-500
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14734726-Acute Disease,
pubmed-meshheading:14734726-Animals,
pubmed-meshheading:14734726-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14734726-Cell Membrane,
pubmed-meshheading:14734726-Chronic Disease,
pubmed-meshheading:14734726-Cytokines,
pubmed-meshheading:14734726-DNA-Binding Proteins,
pubmed-meshheading:14734726-Epitopes, T-Lymphocyte,
pubmed-meshheading:14734726-Immunodominant Epitopes,
pubmed-meshheading:14734726-Immunologic Memory,
pubmed-meshheading:14734726-Immunophenotyping,
pubmed-meshheading:14734726-Interferon-gamma,
pubmed-meshheading:14734726-Lymphocytic Choriomeningitis,
pubmed-meshheading:14734726-Lymphocytic choriomeningitis virus,
pubmed-meshheading:14734726-Mice,
pubmed-meshheading:14734726-Mice, Inbred C57BL,
pubmed-meshheading:14734726-Mice, Knockout,
pubmed-meshheading:14734726-Proto-Oncogene Proteins,
pubmed-meshheading:14734726-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:14734726-Proto-Oncogene Proteins c-bcl-6,
pubmed-meshheading:14734726-Receptors, Interferon,
pubmed-meshheading:14734726-Transcription Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Effect of chronic viral infection on epitope selection, cytokine production, and surface phenotype of CD8 T cells and the role of IFN-gamma receptor in immune regulation.
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pubmed:affiliation |
Department of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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