Source:http://linkedlifedata.com/resource/pubmed/id/14734093
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
2004-1-21
|
pubmed:abstractText |
During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies.
|
pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/CA 15704,
http://linkedlifedata.com/resource/pubmed/grant/CA 18029,
http://linkedlifedata.com/resource/pubmed/grant/CA 78902,
http://linkedlifedata.com/resource/pubmed/grant/DK 42716,
http://linkedlifedata.com/resource/pubmed/grant/HL36444,
http://linkedlifedata.com/resource/pubmed/grant/U54 HD47175
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0188-4409
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
34
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
528-44
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:14734093-Animals,
pubmed-meshheading:14734093-Graft vs Host Disease,
pubmed-meshheading:14734093-HLA Antigens,
pubmed-meshheading:14734093-Hematologic Diseases,
pubmed-meshheading:14734093-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:14734093-History, 20th Century,
pubmed-meshheading:14734093-History, 21st Century,
pubmed-meshheading:14734093-Humans,
pubmed-meshheading:14734093-Transplantation, Homologous,
pubmed-meshheading:14734093-Transplantation Chimera,
pubmed-meshheading:14734093-Transplantation Conditioning,
pubmed-meshheading:14734093-Transplantation Immunology
|
pubmed:articleTitle |
Hematopoietic cell transplantation: five decades of progress.
|
pubmed:affiliation |
Transplantation Biology Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Historical Article,
Research Support, Non-U.S. Gov't
|