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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0005823,
umls-concept:C0007226,
umls-concept:C0011882,
umls-concept:C0018810,
umls-concept:C0022885,
umls-concept:C0033105,
umls-concept:C0086022,
umls-concept:C0205419,
umls-concept:C0392366,
umls-concept:C0442335,
umls-concept:C0741307,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1306673,
umls-concept:C1442989,
umls-concept:C1516048,
umls-concept:C1704632,
umls-concept:C1705099,
umls-concept:C1706817,
umls-concept:C1883073,
umls-concept:C2911692
|
| pubmed:issue |
9
|
| pubmed:dateCreated |
1993-2-1
|
| pubmed:abstractText |
To establish a test battery for the detection and characterization of cardiovascular autonomic neuropathy (CADN) and to evaluate its prevalence, a number of autonomic function tests based on spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses were performed in 261 diabetic patients aged 11-76 years with various stages of peripheral neuropathy. The percentages of abnormal results in the individual tests based on heart rate variation were 6-31% in 115 patients without peripheral neuropathy, 16-45% in 61 patients with subclinical neuropathy, 22-59% in 73 patients with symptomatic peripheral neuropathy, and 67-100% in 12 patients with the latter in conjunction with autonomic symptoms (p < 0.05). The most frequently abnormal indices, each representing a different physiological basis, were the coefficient of variation, low-frequency and mid-frequency power spectrum at rest, mean circular resultant, postural change in systolic blood pressure, and, in particular, the max/min 30:15 ratio and Valsalva ratio. CADN, defined as the presence of > or = 3 abnormalities among these seven parameters was detected in none of 120 control subjects, 13.0% of the patients without peripheral neuropathy, 34.4% of those with subclinical neuropathy, 49.3% of those with symptomatic peripheral neuropathy, and in 100% of the subjects with the latter and concomitant autonomic symptoms (p < 0.05). The overall prevalence of CADN in 103 patients completing all parameters was 46.6%. The corresponding rate of CADN defined as > or = 2 abnormalities among the five tests included in an optimized version of the battery proposed by Ewing and Clarke was 38.8%.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0742-3071
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
806-14
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:1473320-Adolescent,
pubmed-meshheading:1473320-Adult,
pubmed-meshheading:1473320-Aged,
pubmed-meshheading:1473320-Autonomic Nervous System Diseases,
pubmed-meshheading:1473320-Blood Pressure,
pubmed-meshheading:1473320-Cardiovascular System,
pubmed-meshheading:1473320-Child,
pubmed-meshheading:1473320-Diabetic Neuropathies,
pubmed-meshheading:1473320-Female,
pubmed-meshheading:1473320-Germany,
pubmed-meshheading:1473320-Heart Function Tests,
pubmed-meshheading:1473320-Heart Rate,
pubmed-meshheading:1473320-Humans,
pubmed-meshheading:1473320-Male,
pubmed-meshheading:1473320-Middle Aged,
pubmed-meshheading:1473320-Prevalence,
pubmed-meshheading:1473320-Spectrum Analysis
|
| pubmed:year |
1992
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| pubmed:articleTitle |
Prevalence of cardiovascular autonomic dysfunction assessed by spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses at various stages of diabetic neuropathy.
|
| pubmed:affiliation |
Diabetes Research Institute, Heinrich-Heine-University, Düsseldorf, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|