Linked Life Data

14733132

Source:http://linkedlifedata.com/resource/pubmed/id/14733132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2004-1-21
pubmed:abstractText
We investigated the vitreous in its origin, morphology, metabolism and regeneration, and its role in various vitreomacular diseases. Focal vitreous liquefaction developed anterior to a laser induced chorioretinal scar in rabbit eyes, which suggested that a normal retina is necessary to maintain the integrity of the vitreous. We measured levels of hyaluronic acid and of the precursor of type II collagen in vitreous samples obtained by vitrectomy. Those levels declined with age in women. The precursor of type II collagen was at the same level in the samples from vitrectomy and those obtained by fluid air exchange, which suggested a persistent secretion of type II collagen into the vitreous cavity even after vitrectomy. We found a posterior precortical vitreous pocket in human autopsied eyes whose vitreous was stained with fluorescein. Using the same methods, we confirmed the presence of intravitreal fibrous membranes in the "tractus" in the anterior vitreous. In clinical studies using biomicroscopy, observations during surgery, scanning laser ophthalmoscopy, and optical coherence tomography (OCT), we clarified the role of premacular vitreous cortex which forms the posterior wall of the "pocket" in the premacular membrane and macular hole. The premacular vitreous cortex seems to be the main structure of the premacular membrane and its contraction may cause macular hole. Ring-shaped proliferation tends to develop along the outer margin of the "pocket". OCT demonstrated that some diabetic macular edema is caused by traction of the premacular vitreous cortex. Vitrectomy appear to be effective for diabetic macular edema by eliminating vitreous traction and the accumulated cytokine in the "pocket". The retina appears to have a program for vitreous metabolism throughout life, including the premacular pocket formation.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0029-0203
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
813-34; discussion 835
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Vitreous and macular diseases].
pubmed:affiliation
Department of Ophthalmology, Gunma University Postgraduate School of Medicine.
pubmed:publicationType
Journal Article, English Abstract, Review