Linked Life Data

14732882

Source:http://linkedlifedata.com/resource/pubmed/id/14732882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-1-20
pubmed:abstractText
Based on the observation of a small proportion of long-term responses the use of biotherapy or biochemotherapy is currently preferred in many institutions as first line treatment in stage IV melanoma, but still the outcome for patients with stage IV melanoma is unsatisfactory. Various interleukin 2 (IL-2) dosing schedules and combinations with interferon alpha (IFN-alpha) have been tested in patients with advanced melanoma in phase I and II studies. The response rate reported with cytokines alone (IL-2 as a single agent or in combination with IFN-alpha) varies from 10-41%. Subsequently, biochemotherapy regimens combining IL-2, IFN-alpha and chemotherapy have been evaluated in phase II trials suggesting improved response rates. Recent randomised trials have investigated the role of biochemotherapy as compared to biotherapy alone or as compared to chemotherapy for the treatment of advanced melanoma. So far, none of the approaches has been proven to confer a survival benefit and thus the uniform desire is to include as many patients as possible into controlled clinical trials. Therefore current trials are under way trying to improve the efficacy of immunotherapy alone by adding histamine or vaccines to IL-2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1121-8142
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-65; quiz 189
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Biochemotherapy of melanoma.
pubmed:affiliation
Department of Medicine III (Hematology, Oncology and Transfusion Medicine), Charité, Campus Benjamin Franklin, Free University Berlin, Germany.
pubmed:publicationType
Journal Article, Review