Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-1-30
pubmed:abstractText
Chromosome 2 has been consistently identified as a genomic region with genetic linkage evidence suggesting that one or more loci contributes to blood pressure and hypertension status. As with all complex disease traits, following-up linkage evidence to identify the underlying susceptibility gene(s) is an arduous yet biologically and clinically important task. Using combined positional candidate gene methods, the Family Blood Pressure Program (FBPP) has concentrated efforts in narrowing a large region of chromosome 2, demonstrating evidence for linkage in several populations, and identifying underlying candidate hypertension susceptibility gene(s). Initial informatics efforts identified the boundaries of the region and the known genes within it. A total of 82 polymorphic sites in 8 genes were genotyped in a large hypothesis-generating sample consisting of 1640 African Americans, 1339 whites, and 1616 Mexican Americans. After resampling-based false discovery adjustment, SLC4A5, a sodium bicarbonate transporter, was identified as a primary candidate gene for hypertension. Polymorphisms in SLC4A5 were subsequently genotyped and analyzed for validation in two other subcomponents of the FBPP, each contributing African Americans (N=461; N=778) and whites (N=550; N=967). Again, single nucleotide polymorphisms within this gene were significantly associated with blood pressure levels and hypertension status. Although not identifying a single causal gene variant that is significantly associated with blood pressure levels and hypertension status across all samples, the results further implicate SLC4A5 as a candidate hypertension susceptibility gene. Moreover, the present study validates previous evidence for one or more genes on chromosome 2 that influence hypertension-related phenotypes in the population-at-large.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/HL54457, http://linkedlifedata.com/resource/pubmed/grant/HL54463, http://linkedlifedata.com/resource/pubmed/grant/HL54464, http://linkedlifedata.com/resource/pubmed/grant/HL54466, http://linkedlifedata.com/resource/pubmed/grant/HL54471, http://linkedlifedata.com/resource/pubmed/grant/HL54472, http://linkedlifedata.com/resource/pubmed/grant/HL54473, http://linkedlifedata.com/resource/pubmed/grant/HL54481, http://linkedlifedata.com/resource/pubmed/grant/HL54485, http://linkedlifedata.com/resource/pubmed/grant/HL54495, http://linkedlifedata.com/resource/pubmed/grant/HL54496, http://linkedlifedata.com/resource/pubmed/grant/HL54497, http://linkedlifedata.com/resource/pubmed/grant/HL54504, http://linkedlifedata.com/resource/pubmed/grant/HL54508, http://linkedlifedata.com/resource/pubmed/grant/HL54509, http://linkedlifedata.com/resource/pubmed/grant/HL54512, http://linkedlifedata.com/resource/pubmed/grant/HL54526, http://linkedlifedata.com/resource/pubmed/grant/HL64777
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
477-82
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Positional identification of hypertension susceptibility genes on chromosome 2.
pubmed:affiliation
Human Genetics Center and Institute of Molecular Medicine, of Texas Health Science Center at Houston, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't