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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0003483,
umls-concept:C0017262,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0079281,
umls-concept:C0205263,
umls-concept:C0600388,
umls-concept:C1135918,
umls-concept:C1704259,
umls-concept:C1705987
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-20
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pubmed:abstractText |
Angiotensin II (Ang II) increases vascular endothelin-1 (ET-1) tissue levels, which in turn mediate a major part of Ang II-stimulated vascular growth and hypertension in vivo. Ang II also stimulates reactive oxygen species (ROS) generation in vascular smooth muscle cells (SMCs). However, whether ROS are involved in Ang II-induced ET-1 gene expression and the related intracellular mechanisms in vascular SMCs remains to be determined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Azepines,
http://linkedlifedata.com/resource/pubmed/chemical/BQ 485,
http://linkedlifedata.com/resource/pubmed/chemical/Butadienes,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin A,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/U 0126
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14732213-Angiotensin II,
pubmed-meshheading:14732213-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:14732213-Animals,
pubmed-meshheading:14732213-Antioxidants,
pubmed-meshheading:14732213-Aorta,
pubmed-meshheading:14732213-Azepines,
pubmed-meshheading:14732213-Binding Sites,
pubmed-meshheading:14732213-Butadienes,
pubmed-meshheading:14732213-Cells, Cultured,
pubmed-meshheading:14732213-Endothelin-1,
pubmed-meshheading:14732213-Gene Expression,
pubmed-meshheading:14732213-MAP Kinase Signaling System,
pubmed-meshheading:14732213-Male,
pubmed-meshheading:14732213-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14732213-Muscle, Smooth, Vascular,
pubmed-meshheading:14732213-Nitriles,
pubmed-meshheading:14732213-Oligopeptides,
pubmed-meshheading:14732213-Phosphorylation,
pubmed-meshheading:14732213-Rats,
pubmed-meshheading:14732213-Rats, Sprague-Dawley,
pubmed-meshheading:14732213-Reactive Oxygen Species,
pubmed-meshheading:14732213-Receptor, Endothelin A,
pubmed-meshheading:14732213-Transcription Factor AP-1
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pubmed:year |
2004
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pubmed:articleTitle |
Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells.
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pubmed:affiliation |
School of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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