Source:http://linkedlifedata.com/resource/pubmed/id/14729641
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-1-19
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pubmed:abstractText |
Resistance to chemotherapy is responsible for a failure of current treatment regimens in cancer patients. We have reported previously that the Y-box protein YB-1 regulates expression of the P-glycoprotein gene mdr1, which plays a major role in the development of a multidrug resistant-tumor phenotype. YB-1 predicts drug resistance and patient outcome in breast cancer. Thus, YB-1 is a promising target for new therapeutic approaches to defeat multidrug resistance. In drug-resistant cancer cells and in adenovirus-infected cells YB-1 is found in the nucleus. Nuclear accumulation of YB-1 in adenovirus-infected cells is a function of the E1 region, and we have shown that YB-1 facilitates adenovirus replication. Here we report that E1A-deleted or mutant adenovirus vectors, such as Ad312 and Ad520, replicate efficiently in multidrug-resistant (MDR) cancer cells and induce an adenovirus cytopathic effect resulting in host cell lysis. Thus, replication-defective adenoviruses are a previously unrecognized vector system for a selective elimination of MDR cancer cells. Our work forms the basis for the development of novel oncolytic adenovirus vectors for the treatment of MDR malignant diseases in the clinical setting.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:BergmannStephanS,
pubmed-author:BernshausenAlexandraA,
pubmed-author:DietelManfredM,
pubmed-author:GänsbacherBerndB,
pubmed-author:GlockzinGabrielG,
pubmed-author:HolmPer SPS,
pubmed-author:JürchottKarstenK,
pubmed-author:LadhoffAxelA,
pubmed-author:LageHermannH,
pubmed-author:MantwillKlausK,
pubmed-author:MymrykJoe SJS,
pubmed-author:RitterThomasT,
pubmed-author:RoyerHans-DieterHD,
pubmed-author:WichertAnkeA
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
322-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14729641-Adenovirus E1A Proteins,
pubmed-meshheading:14729641-Adenoviruses, Human,
pubmed-meshheading:14729641-Base Sequence,
pubmed-meshheading:14729641-Cell Line,
pubmed-meshheading:14729641-Cell Line, Tumor,
pubmed-meshheading:14729641-DNA, Complementary,
pubmed-meshheading:14729641-DNA Primers,
pubmed-meshheading:14729641-Drug Resistance, Multiple,
pubmed-meshheading:14729641-Gene Deletion,
pubmed-meshheading:14729641-Gene Therapy,
pubmed-meshheading:14729641-HeLa Cells,
pubmed-meshheading:14729641-Humans,
pubmed-meshheading:14729641-Neoplasms,
pubmed-meshheading:14729641-Transfection,
pubmed-meshheading:14729641-Virus Replication
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pubmed:year |
2004
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pubmed:articleTitle |
Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy.
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pubmed:affiliation |
Institut für Experimentelle Onkologie und Therapieforschung, Technische Universität München, Klinikum Rechts der Isar, München, Germany. per.s.holm@lrz.tum.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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