Source:http://linkedlifedata.com/resource/pubmed/id/14729607
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-1-19
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pubmed:abstractText |
We have established previously a mouse strain containing a mutant beta-catenin allele of which exon 3 was sandwiched by loxP sequences [Catnb(lox(ex3))]. In this mouse strain, a Wnt-activating beta-catenin mutation alone is insufficient for hepatocarcinogenesis, but additional mutations or epigenetic changes may be required. Here we report that hepatocellular carcinoma develops at the 100% incidence in mice with simultaneous mutations in the beta-catenin and H-ras genes that are introduced by adenovirus-mediated Cre expression. Although H-ras mutation alone rapidly causes large cell dysplasia in the hepatocytes, these cells show no autonomous growth within 1 week after infection of the Cre-adenovirus. However, simultaneous induction of an additional mutation in the beta-catenin gene causes a clonal expansion of such dysplastic cells, followed by nodular formation and development of hepatocellular carcinoma. These results indicate that beta-catenin mutations play a critical role in hepatocarcinogenesis in cooperation with another oncogene and that these mice provide a convenient model to investigate early steps of hepatocarcinogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-5472
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14729607-Animals,
pubmed-meshheading:14729607-Carcinoma, Hepatocellular,
pubmed-meshheading:14729607-Cytoskeletal Proteins,
pubmed-meshheading:14729607-Exons,
pubmed-meshheading:14729607-Genes, ras,
pubmed-meshheading:14729607-Humans,
pubmed-meshheading:14729607-Liver Neoplasms,
pubmed-meshheading:14729607-Mice,
pubmed-meshheading:14729607-Mice, Transgenic,
pubmed-meshheading:14729607-Time Factors,
pubmed-meshheading:14729607-Trans-Activators,
pubmed-meshheading:14729607-beta Catenin
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pubmed:year |
2004
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pubmed:articleTitle |
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations.
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pubmed:affiliation |
Banyu Tsukuba Research Institute (Merck), Tsukuba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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