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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-1-19
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pubmed:abstractText |
Animal beddings, such as pine products, and environmental factors are known to induce liver drug-metabolizing cytochrome P450 enzymes. We observed that a change to pine-based rat bedding altered baseline and cAMP-stimulated rates of acidification in rat liver endosomes, apparently by decreasing ATP-dependent proton transport in the presence and absence of chloride. Although cAMP altered phosphorylation of protein kinase B and extracellular signal-regulated kinases 1 and 2 (ERK 1,2) and p38 mitogen-activated protein kinases, changes in housing conditions did not affect baseline or cAMP-stimulated values of these or other selected signaling molecules. We conclude that compounds in rat bedding may alter not only drug metabolism, but also aspects of endocytosis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1532-0820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
616-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14727809-Adenosine Triphosphate,
pubmed-meshheading:14727809-Animal Husbandry,
pubmed-meshheading:14727809-Animals,
pubmed-meshheading:14727809-Animals, Laboratory,
pubmed-meshheading:14727809-Beds,
pubmed-meshheading:14727809-Cholera Toxin,
pubmed-meshheading:14727809-Cyclic AMP,
pubmed-meshheading:14727809-Endosomes,
pubmed-meshheading:14727809-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:14727809-Housing, Animal,
pubmed-meshheading:14727809-Hydrogen-Ion Concentration,
pubmed-meshheading:14727809-Injections, Intraperitoneal,
pubmed-meshheading:14727809-Liver,
pubmed-meshheading:14727809-Male,
pubmed-meshheading:14727809-Rats,
pubmed-meshheading:14727809-Rats, Inbred WF,
pubmed-meshheading:14727809-Signal Transduction,
pubmed-meshheading:14727809-Specific Pathogen-Free Organisms,
pubmed-meshheading:14727809-Wood
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pubmed:year |
2003
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pubmed:articleTitle |
Effect of animal bedding on rat liver endosome acidification.
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pubmed:affiliation |
Medical Service, 11R Research Service, Ann Arbor VA Hospital, 2215 Fuller Road, Ann Arbor, Michigan 48105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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