Linked Life Data

14727525

Source:http://linkedlifedata.com/resource/pubmed/id/14727525

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-1-19
pubmed:abstractText
Interaction of function and localization of receptors, especially the 5-hydroxytryptamine4 (5-HT4) receptor was examined in relation to the motility of gastrointestinal tract. The responses mediated by stimulation of 5-HT4 receptor appear to differ with different localization of receptor. The 5-HT4 receptor-mediated acceleration of acetylcholine (ACh) release in the preparations isolated from gastric antrum and corpus, but not fundus, of guinea pig corresponded to the presence of 5-HT4 receptor in the myenteric plexus. The 5-HT4 receptor-mediated response was predominant in the 5-HT-induced acceleration of motility associated with ACh release in the intestine of the whole body of dogs, and the 5-HT4 receptor was localized on the myenteric plexus of dog intestine. Local administration of GABA into intestinal marginal artery reduced the motility associated with ACh release in the intestine of whole body of dogs, and thus response via the inhibitory GABAB receptor was more predominant than that via excitatory GABAA receptor. The GABAB receptor is the first G protein-coupled receptor discovered to form heterodimers, consisted of GABAB1 and GABAB2. There are isoforms of GABAB1, from GABAB1(a) to GABAB1(g), and therefore the function and localization of the GABAB receptor may vary with the different isoforms of GABAB1.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0015-5691
pubmed:author
pubmed:issnType
Print
pubmed:volume
122 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63P-66P
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Functional difference of prokinetics depending on subtypes and localization of receptor in alimentary tract].
pubmed:affiliation
Division of Pharmacology, Department of Translational Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
pubmed:publicationType
Journal Article, English Abstract