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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0021311,
umls-concept:C0033684,
umls-concept:C0035028,
umls-concept:C0038435,
umls-concept:C0311417,
umls-concept:C0392747,
umls-concept:C0439849,
umls-concept:C0443172,
umls-concept:C0445223,
umls-concept:C0445750,
umls-concept:C0449943,
umls-concept:C1167395,
umls-concept:C1314792,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
3
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pubmed:dateCreated |
2004-1-16
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|
pubmed:abstractText |
The NaCl sensitivity of Salmonella enterica serovar Oranienburg strains depends on their origin. We found previously that food- and patient-origin isolates in an outbreak were, respectively, NaCl-resistant and NaCl-sensitive, and the NaCl-resistant strain of food-origin isolates became NaCl-sensitive after passage of the strain through mice [FEMS Microbiol. Lett. 212 (2002) 87]. Here, we report that this phenotypic difference is mainly dependent on topological changes regulated by H-NS, a bacterial histone-like nucleoid protein that binds non-specifically to DNA. That is, this phenotypic difference was caused by changes in DNA topology during infection of the host. Based on these findings, we propose this mechanism has a key role in promoting the survival of Salmonella under osmotic stress.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Superhelical,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/H-NS protein, bacteria,
http://linkedlifedata.com/resource/pubmed/chemical/Sigma Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/sigma factor KatF protein, Bacteria
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0882-4010
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14726232-Animals,
pubmed-meshheading:14726232-Bacterial Proteins,
pubmed-meshheading:14726232-DNA, Bacterial,
pubmed-meshheading:14726232-DNA, Superhelical,
pubmed-meshheading:14726232-DNA-Binding Proteins,
pubmed-meshheading:14726232-Decapodiformes,
pubmed-meshheading:14726232-Feces,
pubmed-meshheading:14726232-Gene Expression Regulation, Bacterial,
pubmed-meshheading:14726232-Genes, Bacterial,
pubmed-meshheading:14726232-Humans,
pubmed-meshheading:14726232-Mice,
pubmed-meshheading:14726232-Osmotic Pressure,
pubmed-meshheading:14726232-Plasmids,
pubmed-meshheading:14726232-Salmonella Food Poisoning,
pubmed-meshheading:14726232-Salmonella Infections,
pubmed-meshheading:14726232-Salmonella Infections, Animal,
pubmed-meshheading:14726232-Salmonella enterica,
pubmed-meshheading:14726232-Sigma Factor,
pubmed-meshheading:14726232-Sodium Chloride,
pubmed-meshheading:14726232-Spleen
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pubmed:year |
2004
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pubmed:articleTitle |
Changes in Salmonella enterica serovar Oranienburg viability caused by NaCl-induced osmotic stress is related to DNA relaxation by the H-NS protein during host infection.
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pubmed:affiliation |
Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, 080-8555, Hokkaido, Japan
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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