Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-1-16
pubmed:abstractText
In this paper, a review of the literature on the methods for the detection of FT(4) is provided. Furthermore, an overview of the most important uncertainties and interferences of the potential reference methods for determination of free thyroxine (free triiodothyronine) are also presented. Especially, the separation step-dialysis, or ultrafiltration-implies important technical and theoretical uncertainties and interferences as to the methods.Furthermore, a short review of methods based on isotope dilution/mass spectrometry (ID/MS) to quantify thyroxine is provided. There has so far been no attempt to quantify the free fraction of thyroxine by ID/MS, probably due to lack of sensitivity, but if quantification of the free fraction of thyroxine can be done with ID/MS, then this step seems the least compromised step only including minor uncertainties in comparison to the separation step.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-9120
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-93
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:14725937-Calibration, pubmed-meshheading:14725937-Chromatography, Liquid, pubmed-meshheading:14725937-Dialysis, pubmed-meshheading:14725937-Evaluation Studies as Topic, pubmed-meshheading:14725937-Gas Chromatography-Mass Spectrometry, pubmed-meshheading:14725937-Humans, pubmed-meshheading:14725937-Hydrogen-Ion Concentration, pubmed-meshheading:14725937-Indicator Dilution Techniques, pubmed-meshheading:14725937-Reference Standards, pubmed-meshheading:14725937-Reproducibility of Results, pubmed-meshheading:14725937-Research Design, pubmed-meshheading:14725937-Sensitivity and Specificity, pubmed-meshheading:14725937-Spectrometry, Mass, Electrospray Ionization, pubmed-meshheading:14725937-Temperature, pubmed-meshheading:14725937-Thyroid Hormones, pubmed-meshheading:14725937-Thyroxine, pubmed-meshheading:14725937-Ultrafiltration
pubmed:year
2004
pubmed:articleTitle
Reference methods for the measurement of free thyroid hormones in blood: evaluation of potential reference methods for free thyroxine.
pubmed:affiliation
Department of Clinical Biochemistry, Holbaek Hospital, 4300 Holbaek, Denmark. chstho@vestamt.dk
pubmed:publicationType
Journal Article, Review