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rdf:type |
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lifeskim:mentions |
umls-concept:C0014556,
umls-concept:C0017801,
umls-concept:C0019564,
umls-concept:C0086418,
umls-concept:C0220839,
umls-concept:C0441712,
umls-concept:C0442818,
umls-concept:C0521119,
umls-concept:C0549183,
umls-concept:C1517945,
umls-concept:C1708982
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pubmed:issue |
9402
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|
pubmed:dateCreated |
2004-1-15
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|
pubmed:abstractText |
High extracellular glutamate concentrations have been identified as a likely trigger of epileptic seizures in mesial temporal lobe epilepsy (MTLE), but the underlying mechanism remains unclear. We investigated whether a deficiency in glutamine synthetase, a key enzyme in catabolism of extracellular glutamate in the brain, could explain the perturbed glutamate homoeostasis in MTLE.
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pubmed:grant |
|
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1474-547X
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:day |
3
|
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pubmed:volume |
363
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
28-37
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14723991-Adolescent,
pubmed-meshheading:14723991-Adult,
pubmed-meshheading:14723991-Astrocytes,
pubmed-meshheading:14723991-Blotting, Western,
pubmed-meshheading:14723991-Child,
pubmed-meshheading:14723991-Epilepsy, Temporal Lobe,
pubmed-meshheading:14723991-Excitatory Amino Acid Transporter 2,
pubmed-meshheading:14723991-Extracellular Space,
pubmed-meshheading:14723991-Female,
pubmed-meshheading:14723991-Glutamate-Ammonia Ligase,
pubmed-meshheading:14723991-Glutamic Acid,
pubmed-meshheading:14723991-Hippocampus,
pubmed-meshheading:14723991-Humans,
pubmed-meshheading:14723991-Immunohistochemistry,
pubmed-meshheading:14723991-Male,
pubmed-meshheading:14723991-Middle Aged,
pubmed-meshheading:14723991-Temporal Lobe
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pubmed:year |
2004
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|
pubmed:articleTitle |
Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy.
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|
pubmed:affiliation |
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA. tore.eid@yale.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
