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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-13
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pubmed:abstractText |
Constrictive remodeling and new artery wall mass contribute to lumen narrowing in atherosclerosis and following injury. Rho-kinase, an important regulator of myosin phosphorylation and cytoskeletal reorganization, is critical to smooth muscle cell (SMC) growth and vasoconstriction, but its role in artery wall remodeling is poorly defined. We hypothesized that constrictive artery wall remodeling is dependent on Rho signaling so that blocking Rho-kinase would promote outward artery wall remodeling in response to intimal hyperplasia and thus limit lumen narrowing.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0741-5214
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14718843-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:14718843-Animals,
pubmed-meshheading:14718843-Aorta,
pubmed-meshheading:14718843-Carotid Arteries,
pubmed-meshheading:14718843-Cells, Cultured,
pubmed-meshheading:14718843-Collagen,
pubmed-meshheading:14718843-Dose-Response Relationship, Drug,
pubmed-meshheading:14718843-Enzyme Inhibitors,
pubmed-meshheading:14718843-Gels,
pubmed-meshheading:14718843-Hyperplasia,
pubmed-meshheading:14718843-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:14718843-Male,
pubmed-meshheading:14718843-Mice,
pubmed-meshheading:14718843-Mice, Inbred C57BL,
pubmed-meshheading:14718843-Muscle, Smooth, Vascular,
pubmed-meshheading:14718843-Protein-Serine-Threonine Kinases,
pubmed-meshheading:14718843-Tunica Intima,
pubmed-meshheading:14718843-rho-Associated Kinases
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pubmed:year |
2004
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pubmed:articleTitle |
Differential effects of Rho-kinase inhibition on artery wall mass and remodeling.
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pubmed:affiliation |
Division of Surgical Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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