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pubmed-article:14718718pubmed:abstractTextIdiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.lld:pubmed
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pubmed-article:14718718pubmed:articleTitleHypocretin-1 CSF levels in anti-Ma2 associated encephalitis.lld:pubmed
pubmed-article:14718718pubmed:affiliationDepartment of Neurology, Leiden University Medical Centre, the Netherlands.lld:pubmed
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