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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-13
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pubmed:abstractText |
Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
138-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14718718-Adenocarcinoma,
pubmed-meshheading:14718718-Adult,
pubmed-meshheading:14718718-Aged,
pubmed-meshheading:14718718-Aged, 80 and over,
pubmed-meshheading:14718718-Antigens, Neoplasm,
pubmed-meshheading:14718718-Autoimmune Diseases of the Nervous System,
pubmed-meshheading:14718718-Carrier Proteins,
pubmed-meshheading:14718718-Encephalitis,
pubmed-meshheading:14718718-Female,
pubmed-meshheading:14718718-Humans,
pubmed-meshheading:14718718-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:14718718-Lung Neoplasms,
pubmed-meshheading:14718718-Male,
pubmed-meshheading:14718718-Middle Aged,
pubmed-meshheading:14718718-Narcolepsy,
pubmed-meshheading:14718718-Nerve Tissue Proteins,
pubmed-meshheading:14718718-Neuropeptides,
pubmed-meshheading:14718718-Ovarian Neoplasms,
pubmed-meshheading:14718718-Paraneoplastic Syndromes, Nervous System,
pubmed-meshheading:14718718-Proteins,
pubmed-meshheading:14718718-Testicular Neoplasms
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pubmed:year |
2004
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pubmed:articleTitle |
Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.
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pubmed:affiliation |
Department of Neurology, Leiden University Medical Centre, the Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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