|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2004-1-13
|
|
pubmed:abstractText |
Pathological shear stress induces platelet aggregation that is dependent on von Willebrand factor (VWF) binding to glycoprotein (Gp)Ib-IX-V and phosphatidylinositol 3-kinase activation. We tested the hypothesis that pathological shear stress stimulates phosphatidylinositol 3,4,5-trisphosphate (PIP3) synthesis by directing the assembly of a molecular signaling complex that includes class IA phosphatidylinositol 3-kinase (PI 3-KIA).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1538-7933
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
161-9
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:14717980-Actinin,
pubmed-meshheading:14717980-Blood Platelets,
pubmed-meshheading:14717980-Humans,
pubmed-meshheading:14717980-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:14717980-Phosphatidylinositol 4,5-Diphosphate,
pubmed-meshheading:14717980-Platelet Glycoprotein GPIb-IX Complex,
pubmed-meshheading:14717980-Protein Binding,
pubmed-meshheading:14717980-Recombinant Proteins,
pubmed-meshheading:14717980-Signal Transduction,
pubmed-meshheading:14717980-Stress, Mechanical,
pubmed-meshheading:14717980-von Willebrand Factor
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
von Willebrand factor binding to platelet glycoprotein Ib-IX-V stimulates the assembly of an alpha-actinin-based signaling complex.
|
|
pubmed:affiliation |
VA Medical Center, Baylor College of Medicine, Rice University, Houston, TX, USA. julio.resendiz@wri.fi
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
