Source:http://linkedlifedata.com/resource/pubmed/id/14716140
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2004-1-12
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pubmed:abstractText |
The combination of docetaxel and cisplatin is one of the standard chemotherapy regimens which has been shown to improve survival and quality of life in patients with advanced non-small cell lung cancer (NSCLC). Docetaxel has therefore been administered by several groups in the neoadjuvant setting in stage-III disease. In combination with cisplatin, the response rate, the complete resection rate and the pathological response rate were similar as in other regimens, postoperative morbidity and mortality, however, seemed reduced when compared with combinations including mitomycin C. Furthermore, there was an association of the chemotherapy activity in mediastinal lymph nodes of patients with a NSCLC (stage IIIA) and overall survival. Based on these results, the cytostatic combination of docetaxel/cisplatin has been chosen for further use in large randomized studies.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0378-584X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2003 S. Karger GmbH, Freiburg
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pubmed:issnType |
Print
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pubmed:volume |
26 Suppl 7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14716140-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:14716140-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:14716140-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:14716140-Cisplatin,
pubmed-meshheading:14716140-Clinical Trials as Topic,
pubmed-meshheading:14716140-Combined Modality Therapy,
pubmed-meshheading:14716140-Humans,
pubmed-meshheading:14716140-Lung Neoplasms,
pubmed-meshheading:14716140-Neoadjuvant Therapy,
pubmed-meshheading:14716140-Neoplasm Staging,
pubmed-meshheading:14716140-Survival Rate,
pubmed-meshheading:14716140-Taxoids
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pubmed:year |
2003
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pubmed:articleTitle |
[Docetaxel in neoadjuvant therapy of early-stage non-small cell carcinoma].
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pubmed:affiliation |
Institut für Medizinische Onkologie, Inselspital, Universität Bern. daniel.betticher@insel.ch
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract,
Review
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