Linked Life Data

1471470

Source:http://linkedlifedata.com/resource/pubmed/id/1471470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-1-26
pubmed:abstractText
Spinal cord of the rat was investigated immunohistochemically to detect signs of extravasation of fibronectin in animals in which the cord was subjected to different degrees of compression trauma. Immunohistochemistry was performed after survival periods of 4 and 24 h and parallel sections were incubated for albumin immunoreactivity to detect signs of breakdown of the blood-spinal cord barrier. Extravascular reaction products indicating the presence of fibronectin were found within and in the vicinity of the compression provided that bleeding had occurred in the spinal cord, i.e., in rats with severe trauma. Immunoreactive material indicating extravascular albumin was present in the traumatized region and in many segments of the cord located away from the compressed part. Such material was seen both proximal and distal to the primary injury and even in rats with a low magnitude of compression. Generally, with more severe trauma and longer survival periods extravascular albumin was more extensively distributed along the cord. No signs of fibronectin antigen were detected in spinal cord segments away from the compression even though such regions showed albumin immunoreactivity outside the vessels. The results indicate that within and close to the primary injury of compressed spinal cord exudation of fibronectin may occur from the plasma of microvessels provided that the impact is severe enough to cause intramedullary hemorrhages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-20
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Exudation of fibronectin and albumin after spinal cord injury in rats.
pubmed:affiliation
Laboratory of Neuropathology, University Hospital, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't