| pubmed-article:1471411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1471411 | lifeskim:mentions | umls-concept:C0008354 | lld:lifeskim |
| pubmed-article:1471411 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:1471411 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:1471411 | lifeskim:mentions | umls-concept:C1520145 | lld:lifeskim |
| pubmed-article:1471411 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:1471411 | pubmed:dateCreated | 1993-1-22 | lld:pubmed |
| pubmed-article:1471411 | pubmed:abstractText | During the last decade there has been a rapid progress in the development of new, much improved vaccines against cholera. These vaccines, which are given orally to stimulate the gut mucosal immune system, are based on either a combination of purified cholera toxin B (binding) subunit and killed cholera vibrios of Inaba and Ogawa serotypes and El Tor and classical biotypes (B subunit-whole cell vaccine, B-WC) or on a live attenuated mutant strain of Vibrio cholerae producing the B subunit (CVD 103-HgR). The safety of the oral B-WC cholera vaccine and the immunogenicity and protective efficacy of this vaccine against both cholera and diarrhoea caused by enterotoxigenic Escherichia coli have been extensively documented, e.g. in a large randomized, placebo-controlled field trial in 90,000 persons living in a cholera endemic area. The potential for inexpensive large-scale manufacturing of the B-WC vaccine has recently been much facilitated by the introduction of recombinant DNA technology for production of the B subunit component. This now gives promise that this vaccine could become a useful, cost-effective tool in future strategies to control cholera both in endemic situations and in relation to acute epidemic outbreaks. | lld:pubmed |
| pubmed-article:1471411 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1471411 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1471411 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1471411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1471411 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:ClemensJJ | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:HolmgrenJJ | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:WigzellHH | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:TATEK BKB | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:SvennerholmA... | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:JertbornMM | lld:pubmed |
| pubmed-article:1471411 | pubmed:author | pubmed-author:SalenstedtRR | lld:pubmed |
| pubmed-article:1471411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1471411 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:1471411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1471411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1471411 | pubmed:pagination | 911-4 | lld:pubmed |
| pubmed-article:1471411 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1471411 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1471411 | pubmed:articleTitle | An oral B subunit: whole cell vaccine against cholera. | lld:pubmed |
| pubmed-article:1471411 | pubmed:affiliation | Department of Medical Microbiology and Immunology, University of Göteborg, Sweden. | lld:pubmed |
| pubmed-article:1471411 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1471411 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1471411 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:1471411 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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