| pubmed-article:14713299 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14713299 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:14713299 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:14713299 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:14713299 | lifeskim:mentions | umls-concept:C0048403 | lld:lifeskim |
| pubmed-article:14713299 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:14713299 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:14713299 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:14713299 | pubmed:dateCreated | 2004-1-9 | lld:pubmed |
| pubmed-article:14713299 | pubmed:abstractText | The present study was undertaken to assess the ability of 4-hydroxytamoxifen (4-OHT) to alter methamphetamine-induced nigrostriatal dopaminergic toxicity. Three daily doses of 4-OHT (6 micro g/day) effectively attenuated methamphetamine-induced nigrostriatal dopamine depletions in both sexes of intact and gonadectomized C57BL/6 J mice. 4-OHT alone did not alter the dopamine content levels in the striatum. Both male and female mice exhibited similar Cu, Zn-superoxide dismutase protein levels in the striata whether after gonadectomy or 4-OHT treatment. Furthermore, basal body temperature and methamphetamine-induced hyperthermia were not affected by 4-OHT treatment in either sex of mice. Using a lucigenen-derived chemiluminescence assay, we found that 4-OHT by itself can serve as a potent superoxide anion radical scavenger in vitro. The protective effects of 4-OHT against methamphetamine-induced nigrostriatal dopamine depletion can be, in part, due to its antioxidative characteristics. The free radical-scavenging ability of 4-OHT calls for further investigations for its uses in clinical practice. | lld:pubmed |
| pubmed-article:14713299 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14713299 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14713299 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14713299 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14713299 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:14713299 | pubmed:author | pubmed-author:KuoYu-MinYM | lld:pubmed |
| pubmed-article:14713299 | pubmed:author | pubmed-author:YuLungL | lld:pubmed |
| pubmed-article:14713299 | pubmed:author | pubmed-author:CherngChianfa... | lld:pubmed |
| pubmed-article:14713299 | pubmed:author | pubmed-author:ChenHsiang-Hu... | lld:pubmed |
| pubmed-article:14713299 | pubmed:author | pubmed-author:ChuangKuo-Pin... | lld:pubmed |
| pubmed-article:14713299 | pubmed:author | pubmed-author:ShiehChih-Cha... | lld:pubmed |
| pubmed-article:14713299 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14713299 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:14713299 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14713299 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14713299 | pubmed:pagination | 1436-43 | lld:pubmed |
| pubmed-article:14713299 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:meshHeading | pubmed-meshheading:14713299... | lld:pubmed |
| pubmed-article:14713299 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14713299 | pubmed:articleTitle | 4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice. | lld:pubmed |
| pubmed-article:14713299 | pubmed:affiliation | Department of Cell Biology and Anatomy, National Cheng Kung University College of Medicine, Tainan, Taiwan. | lld:pubmed |
| pubmed-article:14713299 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14713299 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14713299 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
