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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2004-1-9
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pubmed:abstractText |
The present study was undertaken to assess the ability of 4-hydroxytamoxifen (4-OHT) to alter methamphetamine-induced nigrostriatal dopaminergic toxicity. Three daily doses of 4-OHT (6 micro g/day) effectively attenuated methamphetamine-induced nigrostriatal dopamine depletions in both sexes of intact and gonadectomized C57BL/6 J mice. 4-OHT alone did not alter the dopamine content levels in the striatum. Both male and female mice exhibited similar Cu, Zn-superoxide dismutase protein levels in the striata whether after gonadectomy or 4-OHT treatment. Furthermore, basal body temperature and methamphetamine-induced hyperthermia were not affected by 4-OHT treatment in either sex of mice. Using a lucigenen-derived chemiluminescence assay, we found that 4-OHT by itself can serve as a potent superoxide anion radical scavenger in vitro. The protective effects of 4-OHT against methamphetamine-induced nigrostriatal dopamine depletion can be, in part, due to its antioxidative characteristics. The free radical-scavenging ability of 4-OHT calls for further investigations for its uses in clinical practice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1436-43
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14713299-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:14713299-Animals,
pubmed-meshheading:14713299-Blotting, Western,
pubmed-meshheading:14713299-Body Temperature,
pubmed-meshheading:14713299-Castration,
pubmed-meshheading:14713299-Chromatography, High Pressure Liquid,
pubmed-meshheading:14713299-Dopamine,
pubmed-meshheading:14713299-Dose-Response Relationship, Drug,
pubmed-meshheading:14713299-Drug Interactions,
pubmed-meshheading:14713299-Estrogen Antagonists,
pubmed-meshheading:14713299-Female,
pubmed-meshheading:14713299-Male,
pubmed-meshheading:14713299-Methamphetamine,
pubmed-meshheading:14713299-Mice,
pubmed-meshheading:14713299-Mice, Inbred C57BL,
pubmed-meshheading:14713299-Neostriatum,
pubmed-meshheading:14713299-Neurotoxins,
pubmed-meshheading:14713299-Sex Factors,
pubmed-meshheading:14713299-Superoxide Dismutase,
pubmed-meshheading:14713299-Tamoxifen,
pubmed-meshheading:14713299-Time Factors,
pubmed-meshheading:14713299-Xanthine Oxidase
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pubmed:year |
2003
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pubmed:articleTitle |
4-Hydroxytamoxifen attenuates methamphetamine-induced nigrostriatal dopaminergic toxicity in intact and gonadetomized mice.
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pubmed:affiliation |
Department of Cell Biology and Anatomy, National Cheng Kung University College of Medicine, Tainan, Taiwan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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