Linked Life Data

14713127

Source:http://linkedlifedata.com/resource/pubmed/id/14713127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-1-9
pubmed:abstractText
Regulation of cutaneous vascular tone in humans is complex due to the different types of skin in various regions of the body and the vast array of nerves involved in regulation of blood flow. Due to these complexities, it is unclear how the cutaneous vasculature responds to hypoxia. There are reports of exaggerated vasoconstriction and vasodilation, while others suggest the skin is unresponsive to a hypoxic stimulus. Preliminary work in our laboratory suggests hypoxic vasodilation may be unmasked with alpha-receptor blockade. In contrast to skeletal muscle, hypoxic cutaneous vasodilation is not blunted by beta-blockade, but may be abolished with NO-synthase inhibition. Furthermore, effects of hypoxia on skin blood flow may be more pronounced during combined hypoxic and thermoregulatory challenges. Along these lines, overall thermoregulation may be impacted by hypoxic effects on the cutaneous vasculature and hypobaric effects on sweating and evaporation. During supine heat stress, for example, skin blood flow can increase to 8 Liters per minute. This dramatic rise in skin blood flow is accomplished by an increase in cardiac output and redistribution of blood flow from the splanchnic and renal vascular beds. During hypoxia, splanchnic blood flow has been shown to increase. Thus, during a hypoxic challenge in the heat, a competition for blood flow between the compliant skin and splanchnic regions must exist, but is not well understood. In this review, the effects of hypoxia on the regulation of cutaneous vascular tone and the impact on temperature regulation will be discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
543
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Hypoxic regulation of blood flow in humans. Skin blood flow and temperature regulation.
pubmed:affiliation
Department of Exercise and Movement Science, University of Oregon, Eugene 97403-1240, USA. minson@oregon.uoregon.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review