Linked Life Data

1471217

Source:http://linkedlifedata.com/resource/pubmed/id/1471217

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-1-25
pubmed:abstractText
Rates of cell proliferation, cell death, and cell differentiation affect the risk of cancer profoundly. An increase in cell proliferation rates leads to an increase in mutation rates per unit of time, which, in turn, leads to an increase in the risk of cancer. An increase in cell division rates relative to death or differentiation rates may lead to an increase in the population of critical target cells, which, again, leads to an increase in cancer risk. These fundamental principles are well illustrated by the rodent liver model for carcinogenesis. In this paper, we shall briefly discuss some of the consequences of incorporating cell proliferation kinetics into quantitative models of cancer risk assessment. Consideration of cell kinetics can shed light on apparently paradoxical observations such as, e.g. the observation that the administration of two different promoters may lead to the same volume fraction in the rodent liver, with one promoter giving rise to a large number of small foci, and the other to a small number of large foci. Some consequences of explicitly considering cell proliferation kinetics in malignant foci are briefly discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:volume
64-65 Spec No
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
631-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Risk assessment of non-genotoxic carcinogens.
pubmed:affiliation
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98104.
pubmed:publicationType
Journal Article