|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-1-8
|
|
pubmed:abstractText |
The asymmetric synthesis and biological activity of (2S,1'S,2'R,3'R)-2-(2'-carboxy-3'-hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3' substituted carboxy cyclopropyl glycine is a highly potent group 2 and group 3 mGluR agonist that has proven to be orally active in both fear potentiated startle (animal model for anxiety) and PCP-induced motor activation (animal model for psychosis) assays in rats.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
pubmed-author:Blanco-UrgoitiJaimeJ,
pubmed-author:BuenoAna BelénAB,
pubmed-author:ColladoIvánI,
pubmed-author:GonzálezRosarioR,
pubmed-author:GriffeyKelly IKI,
pubmed-author:HoardDavid WDW,
pubmed-author:JohnsonBryan GBG,
pubmed-author:KingstonAnn EAE,
pubmed-author:MarcosAliciaA,
pubmed-author:MoherEric DED,
pubmed-author:Pérez-CastellsJavierJ,
pubmed-author:PedregalConcepciónC,
pubmed-author:SchoeppDarryle DDD,
pubmed-author:TizzanoJoseph PJP,
pubmed-author:WrightRebecca ARA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
456-66
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:14711315-Administration, Oral,
pubmed-meshheading:14711315-Animals,
pubmed-meshheading:14711315-Cerebral Cortex,
pubmed-meshheading:14711315-Cyclic AMP,
pubmed-meshheading:14711315-Fear,
pubmed-meshheading:14711315-Glycine,
pubmed-meshheading:14711315-Male,
pubmed-meshheading:14711315-Motor Activity,
pubmed-meshheading:14711315-Rats,
pubmed-meshheading:14711315-Rats, Sprague-Dawley,
pubmed-meshheading:14711315-Receptors, Metabotropic Glutamate,
pubmed-meshheading:14711315-Startle Reaction,
pubmed-meshheading:14711315-Stereoisomerism,
pubmed-meshheading:14711315-Structure-Activity Relationship
|
|
pubmed:year |
2004
|
|
pubmed:articleTitle |
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.
|
|
pubmed:affiliation |
Lilly, SA, Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain. collado_ivan@lilly.com
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
