Source:http://linkedlifedata.com/resource/pubmed/id/14709385
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-1-7
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| pubmed:abstractText |
Cultures of neurons can be grown on microelectrode arrays (MEAs), so that their spike and burst activity can be monitored. These activity patterns are quite sensitive to changes in the environment, such as chemical exposure, and hence the cultures can be used as biosensors. One key issue in analyzing the data from neuronal networks is how to quantify the level of synchronization among different units, which represent different neurons in the network. In this paper, we propose a synchronization metric, based on the statistical distribution of unit-to-unit correlation coefficients. We show that this synchronization metric changes significantly when the networks are exposed to bicuculline, strychnine, or 2,3-dioxo-6-nitro-l,2,3,4-tetrahydrobenzoquinoxaline-7-sulphonamide (NBQX). For that reason, this metric can be used to characterize pharmacologically induced changes in a network, either for research or for biosensor applications.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0956-5663
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
675-83
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| pubmed:dateRevised |
2009-7-14
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| pubmed:meshHeading |
pubmed-meshheading:14709385-Action Potentials,
pubmed-meshheading:14709385-Algorithms,
pubmed-meshheading:14709385-Animals,
pubmed-meshheading:14709385-Bicuculline,
pubmed-meshheading:14709385-Biosensing Techniques,
pubmed-meshheading:14709385-Cells, Cultured,
pubmed-meshheading:14709385-Dose-Response Relationship, Drug,
pubmed-meshheading:14709385-Mice,
pubmed-meshheading:14709385-Mice, Inbred ICR,
pubmed-meshheading:14709385-Microelectrodes,
pubmed-meshheading:14709385-Models, Neurological,
pubmed-meshheading:14709385-Models, Statistical,
pubmed-meshheading:14709385-Nerve Net,
pubmed-meshheading:14709385-Neurons,
pubmed-meshheading:14709385-Quinoxalines,
pubmed-meshheading:14709385-Reproducibility of Results,
pubmed-meshheading:14709385-Sensitivity and Specificity,
pubmed-meshheading:14709385-Spinal Cord,
pubmed-meshheading:14709385-Statistics as Topic,
pubmed-meshheading:14709385-Strychnine
|
| pubmed:year |
2004
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| pubmed:articleTitle |
Measuring synchronization in neuronal networks for biosensor applications.
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| pubmed:affiliation |
Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Code 6900, 4555 Overlook Avenue, SW, Washington, DC 20375, USA. jonathan.selinger@nrl.navy.mil
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Evaluation Studies,
Validation Studies
|