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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-3-8
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pubmed:abstractText |
Uptake of modified low-density lipoprotein (LDL) by macrophages through scavenger receptors results in lipid droplets accumulation and foam cell formation. Excess lipid deposition in macrophages has been reported to modulate expression of several genes including adipophilin. In this study, we investigated the function of adipophilin in lipid accumulation and cholesterol efflux in THP-1 macrophages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/acetyl-LDL,
http://linkedlifedata.com/resource/pubmed/chemical/perilipin 2
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
504-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14707038-Apolipoprotein A-I,
pubmed-meshheading:14707038-Carotid Artery Diseases,
pubmed-meshheading:14707038-Cell Differentiation,
pubmed-meshheading:14707038-Cell Line,
pubmed-meshheading:14707038-Cholesterol,
pubmed-meshheading:14707038-Cholesterol Esters,
pubmed-meshheading:14707038-DNA, Complementary,
pubmed-meshheading:14707038-Endarterectomy, Carotid,
pubmed-meshheading:14707038-Foam Cells,
pubmed-meshheading:14707038-Gene Silencing,
pubmed-meshheading:14707038-Humans,
pubmed-meshheading:14707038-Lipid Metabolism,
pubmed-meshheading:14707038-Lipoproteins, LDL,
pubmed-meshheading:14707038-Macrophages,
pubmed-meshheading:14707038-Membrane Proteins,
pubmed-meshheading:14707038-Monocytes,
pubmed-meshheading:14707038-Peptides,
pubmed-meshheading:14707038-RNA, Messenger,
pubmed-meshheading:14707038-RNA, Small Interfering,
pubmed-meshheading:14707038-Receptors, Immunologic,
pubmed-meshheading:14707038-Receptors, Scavenger,
pubmed-meshheading:14707038-Tetradecanoylphorbol Acetate,
pubmed-meshheading:14707038-Transfection,
pubmed-meshheading:14707038-Triglycerides
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pubmed:year |
2004
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pubmed:articleTitle |
Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis.
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pubmed:affiliation |
Department of Atherosclerosis, SERLIA-INSERM UR545, Institut Pasteur de Lille, Lille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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