Linked Life Data

14706922

Source:http://linkedlifedata.com/resource/pubmed/id/14706922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2004-1-8
pubmed:abstractText
The scientific literature publishes many articles reporting results of clinical trials. The criticisms which usually follow show the importance of the trial methodology in all of its aspects, since the results of these trials may have a strategic impact on the treatment of patients in the future. A clinical trial, no matter how many patients are included, will not have the anticipated impact if there are methodological biases. An inappropriate statistical analysis can always be redone, missing data can sometimes be retrieved, but a protocol not correctly followed or an inadequate strategy are fatal errors as far as the value of the conclusions of the trial are concerned. It is not ethical nowadays to start a clinical trial on humans if the results of the trials do not permit a conclusion because of methodological problems or inadequate resources. Each trial should thus be oriented in such a way so that each step is planned with an irreproachable quality by avoiding as much as possible methodological biases. The tendency today, which consists in adapting treatments more and more on an individual basis, will make it more difficult to undertake large simple clinical trials able to answer a simple question. Trials no longer escape the necessity to plan one or more interim analysis, since it is no longer ethical to continue to include patients without even thinking of looking at the results before the expected end of the trial, especially for severe adverse reactions.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-4551
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
919-23
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Increasing the quality of clinical trials in oncology: an important challenge].
pubmed:publicationType
Letter, English Abstract