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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2004-1-5
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pubmed:abstractText |
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0364-5134
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pubmed:author |
pubmed-author:BonifatiVincenzoV,
pubmed-author:EberwineJames HJH,
pubmed-author:HeutinkPeterP,
pubmed-author:HinkleDavid ADA,
pubmed-author:KamphorstWouterW,
pubmed-author:LeeVirginia M-YVM,
pubmed-author:MartinezDanielD,
pubmed-author:RavidRivkaR,
pubmed-author:RizzuPatriziaP,
pubmed-author:SeverijnenLies-AnneLA,
pubmed-author:TrojanowskiJohn QJQ,
pubmed-author:ZhukarevaVictoriaV
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14705119-Aged,
pubmed-meshheading:14705119-Aged, 80 and over,
pubmed-meshheading:14705119-Animals,
pubmed-meshheading:14705119-Brain,
pubmed-meshheading:14705119-COS Cells,
pubmed-meshheading:14705119-Cercopithecus aethiops,
pubmed-meshheading:14705119-Dementia,
pubmed-meshheading:14705119-HeLa Cells,
pubmed-meshheading:14705119-Humans,
pubmed-meshheading:14705119-Immunoblotting,
pubmed-meshheading:14705119-Immunohistochemistry,
pubmed-meshheading:14705119-Inclusion Bodies,
pubmed-meshheading:14705119-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:14705119-Middle Aged,
pubmed-meshheading:14705119-Neurofibrillary Tangles,
pubmed-meshheading:14705119-Oncogene Proteins,
pubmed-meshheading:14705119-Parkinsonian Disorders,
pubmed-meshheading:14705119-Transfection,
pubmed-meshheading:14705119-tau Proteins
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pubmed:year |
2004
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pubmed:articleTitle |
DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
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pubmed:affiliation |
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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