| pubmed-article:14704660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14704660 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:14704660 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:14704660 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:14704660 | lifeskim:mentions | umls-concept:C0152964 | lld:lifeskim |
| pubmed-article:14704660 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:14704660 | pubmed:dateCreated | 2004-1-5 | lld:pubmed |
| pubmed-article:14704660 | pubmed:abstractText | The immunostimulatory activity of viridans streptococcal strains isolated from neutropenic patients with severe sepsis (n=9) or uncomplicated bacteraemia (n=10) was compared. Peripheral blood mononuclear cells from healthy individuals were stimulated with heat-killed bacteria or culture supernatants, and cytokine production assessed. All strains were potent inducers of IL1beta, IL8, and TNFalpha production. Heat-killed bacteria induced consistently higher IL1beta and TNFalpha production than did the cell-free bacterial supernatants (P<0.01). The strains did not induce any proliferative response, nor any significant TNFbeta or IFNgamma production. No difference in cytokine-inducing capacity could be detected between the cohorts of severe and nonsevere isolates. Comparison of strains causing severe and nonsevere episodes in the same patient (n=2) revealed a significantly higher induction of IL1beta by the severe episodes associated isolates as compared to the nonsevere (P<0.04). The study underscores the importance of the host-pathogen interplay in determining the level of inflammation, and hence the severity of disease. | lld:pubmed |
| pubmed-article:14704660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14704660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14704660 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14704660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14704660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14704660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14704660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14704660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14704660 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14704660 | pubmed:issn | 0268-3369 | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:WretlindBB | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:RingdénOO | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:AnderssonJJ | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:HOUP CPC | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:LjungmanPP | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:AlleyJJ | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:RembergerMM | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:SparrelidEE | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:Norrby-Teglun... | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:IhendyaneNN | lld:pubmed |
| pubmed-article:14704660 | pubmed:author | pubmed-author:NormarkB... | lld:pubmed |
| pubmed-article:14704660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14704660 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:14704660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14704660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14704660 | pubmed:pagination | 79-85 | lld:pubmed |
| pubmed-article:14704660 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:meshHeading | pubmed-meshheading:14704660... | lld:pubmed |
| pubmed-article:14704660 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14704660 | pubmed:articleTitle | Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines. | lld:pubmed |
| pubmed-article:14704660 | pubmed:affiliation | Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:14704660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14704660 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14704660 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
