Source:http://linkedlifedata.com/resource/pubmed/id/14704660
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-1-5
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pubmed:abstractText |
The immunostimulatory activity of viridans streptococcal strains isolated from neutropenic patients with severe sepsis (n=9) or uncomplicated bacteraemia (n=10) was compared. Peripheral blood mononuclear cells from healthy individuals were stimulated with heat-killed bacteria or culture supernatants, and cytokine production assessed. All strains were potent inducers of IL1beta, IL8, and TNFalpha production. Heat-killed bacteria induced consistently higher IL1beta and TNFalpha production than did the cell-free bacterial supernatants (P<0.01). The strains did not induce any proliferative response, nor any significant TNFbeta or IFNgamma production. No difference in cytokine-inducing capacity could be detected between the cohorts of severe and nonsevere isolates. Comparison of strains causing severe and nonsevere episodes in the same patient (n=2) revealed a significantly higher induction of IL1beta by the severe episodes associated isolates as compared to the nonsevere (P<0.04). The study underscores the importance of the host-pathogen interplay in determining the level of inflammation, and hence the severity of disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0268-3369
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14704660-Bacteremia,
pubmed-meshheading:14704660-Cells, Cultured,
pubmed-meshheading:14704660-Cytokines,
pubmed-meshheading:14704660-Humans,
pubmed-meshheading:14704660-Inflammation,
pubmed-meshheading:14704660-Interleukin-1,
pubmed-meshheading:14704660-Interleukin-8,
pubmed-meshheading:14704660-Leukocytes, Mononuclear,
pubmed-meshheading:14704660-Neutropenia,
pubmed-meshheading:14704660-Sepsis,
pubmed-meshheading:14704660-Tumor Necrosis Factor-alpha,
pubmed-meshheading:14704660-Viridans Streptococci
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pubmed:year |
2004
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pubmed:articleTitle |
Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines.
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pubmed:affiliation |
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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