14703363

Source:http://linkedlifedata.com/resource/pubmed/id/14703363

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012727, umls-concept:C0205099, umls-concept:C0220781, umls-concept:C0243072, umls-concept:C0332514, umls-concept:C1883254
pubmed:issue	1
pubmed:dateCreated	2004-1-2
pubmed:abstractText	[reaction: see text] Activation of substituted 1,1-diarylmethanols as their corresponding toluenesulfonates and subsequent displacement with a range of carbon, nitrogen, oxygen, and sulfur nucleophiles proceeds in 81-96% yield. Enantiomerically enriched diarylmethanols 8a-c were activated and displaced with pyridine acetate enolate with complete stereochemical inversion at carbon to yield 1,1-diarylalkyl derivatives 10a-c without loss of optical purity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100890393
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Jan
pubmed:issn	1523-7060
pubmed:author	pubmed-author:BolshanYuriY, pubmed-author:ChenCheng-yiCY, pubmed-author:ChilenskiJennifer RJR, pubmed-author:GosselinFrancisF, pubmed-author:MathreDavid JDJ, pubmed-author:O'SheaPaul DPD, pubmed-author:RoyAmélieA, pubmed-author:TillyerRichard DRD
pubmed:issnType	Print
pubmed:day	8
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	111-4
pubmed:year	2004
pubmed:articleTitle	Nucleophilic displacement at benzhydryl centers: asymmetric synthesis of 1,1-diarylalkyl derivatives.
pubmed:affiliation	Department of Process Research, Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, H9R 4P8, Canada.
pubmed:publicationType	Journal Article