| pubmed-article:14701758 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14701758 | lifeskim:mentions | umls-concept:C0242275 | lld:lifeskim |
| pubmed-article:14701758 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:14701758 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:14701758 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:14701758 | lifeskim:mentions | umls-concept:C1333676 | lld:lifeskim |
| pubmed-article:14701758 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:14701758 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:14701758 | pubmed:dateCreated | 2003-12-31 | lld:pubmed |
| pubmed-article:14701758 | pubmed:abstractText | Activation of the mitogen-activated protein kinase pathway represented by extracellular signal-regulated kinases (ERK1/2) and activation of the upstream kinase (MEK1) are critical events for growth factor signal transduction. c-Src has been proposed as a common mediator for these signals in response to both G protein-coupled receptors (GPCRs) and tyrosine kinase-coupled receptors (TKRs). Here we show that the GPCR kinase-interacting protein 1 (GIT1) is a substrate for c-Src that associates with MEK1 in vascular smooth-muscle cells and human embryonic kidney 293 cells. GIT1 binding via coiled-coil domains and a Spa2 homology domain is required for sustained activation of MEK1-ERK1/2 after stimulation with angiotensin II and epidermal growth factor. We propose that GIT1 serves as a scaffold protein to facilitate c-Src-dependent activation of MEK1-ERK1/2 in response to both GPCRs and TKRs. | lld:pubmed |
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| pubmed-article:14701758 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14701758 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14701758 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14701758 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14701758 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:14701758 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:14701758 | pubmed:author | pubmed-author:DaleT JTJ | lld:pubmed |
| pubmed-article:14701758 | pubmed:author | pubmed-author:BerkBradford... | lld:pubmed |
| pubmed-article:14701758 | pubmed:author | pubmed-author:HaendelerJudi... | lld:pubmed |
| pubmed-article:14701758 | pubmed:author | pubmed-author:YinGuoyongG | lld:pubmed |
| pubmed-article:14701758 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14701758 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:14701758 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14701758 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14701758 | pubmed:pagination | 875-85 | lld:pubmed |
| pubmed-article:14701758 | pubmed:dateRevised | 2011-5-6 | lld:pubmed |
