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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-12-31
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pubmed:abstractText |
Activation of the mitogen-activated protein kinase pathway represented by extracellular signal-regulated kinases (ERK1/2) and activation of the upstream kinase (MEK1) are critical events for growth factor signal transduction. c-Src has been proposed as a common mediator for these signals in response to both G protein-coupled receptors (GPCRs) and tyrosine kinase-coupled receptors (TKRs). Here we show that the GPCR kinase-interacting protein 1 (GIT1) is a substrate for c-Src that associates with MEK1 in vascular smooth-muscle cells and human embryonic kidney 293 cells. GIT1 binding via coiled-coil domains and a Spa2 homology domain is required for sustained activation of MEK1-ERK1/2 after stimulation with angiotensin II and epidermal growth factor. We propose that GIT1 serves as a scaffold protein to facilitate c-Src-dependent activation of MEK1-ERK1/2 in response to both GPCRs and TKRs.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10330411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10354709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10428811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10655494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10788515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10856236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10896954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10934473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-10938112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11226259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11266467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11448998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11533043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11741534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11880263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-11959862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12006652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12024021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12031795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12189133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12213567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12361575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12456372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12464621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-12876277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-1528852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-2466788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-2909538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-3280155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-7527386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-7586216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-7746328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-7997267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-8034731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-8348687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-8626602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-8631299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-8649368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9115393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9128257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9287353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9314836,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9632790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9733512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9733513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9758639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9826657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9892142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14701758-9931105
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/GIT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Git1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Git1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Map2k1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
875-85
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pubmed:dateRevised |
2011-5-6
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