Source:http://linkedlifedata.com/resource/pubmed/id/14700596
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-12-31
|
| pubmed:abstractText |
Oligotyping performed among ethnically mixed Venezuelan patients with myasthenia gravis (MG) and controls has revealed positive associations of HLA class I A*31, B*08, B*39, B*40, C*15, C*17, and class II DRB1*09 and negative associations of DQB1*06 and DQA1*02 with the disease. Sequential removal of human leukocyte antigen B (HLA-B) alleles when relative predispositional effects (RPEs) were looked for demonstrated that B*08 is the allele group with the largest contribution in the overall MG patients followed by B*39 and B*40. Several specificities (A*31, B*08, C*17, DRB1*03, DQA1*05, and DQB1*02) indicated increased frequencies among patients with thymic hyperplasia versus patients without hyperplasia or controls. Tests to identify alleles with the strongest association to MG in our patients detected DRB1*13 and B*38 as possible predisposing secondarily associated alleles in patients with hyperplasia. The associations observed disappear after Bonferoni correction of probability values and have been described in patients of Caucasian and/or Oriental ethnic background. Thus, our results reflect the heterogeneity of our population and of the patients tested and suggest a limited influence of several HLA genes in this heterogeneous disease or that these might be only markers of nearby non-HLA genes responsible for the susceptibility or resistance effect.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0198-8859
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
54-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14700596-Adult,
pubmed-meshheading:14700596-Alleles,
pubmed-meshheading:14700596-Autoimmune Diseases,
pubmed-meshheading:14700596-Ethnic Groups,
pubmed-meshheading:14700596-Female,
pubmed-meshheading:14700596-Gene Frequency,
pubmed-meshheading:14700596-Genes, MHC Class I,
pubmed-meshheading:14700596-Genes, MHC Class II,
pubmed-meshheading:14700596-Genetic Predisposition to Disease,
pubmed-meshheading:14700596-Humans,
pubmed-meshheading:14700596-Hyperplasia,
pubmed-meshheading:14700596-Male,
pubmed-meshheading:14700596-Middle Aged,
pubmed-meshheading:14700596-Myasthenia Gravis,
pubmed-meshheading:14700596-Phenotype,
pubmed-meshheading:14700596-Polymorphism, Genetic,
pubmed-meshheading:14700596-Thymoma,
pubmed-meshheading:14700596-Thymus Gland,
pubmed-meshheading:14700596-Thymus Neoplasms,
pubmed-meshheading:14700596-Venezuela
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
HLA class II and class I polymorphism in Venezuelan patients with myasthenia gravis.
|
| pubmed:affiliation |
Centro de Medicina Experimental Miguel Layrisse, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|