Linked Life Data

14698468

Source:http://linkedlifedata.com/resource/pubmed/id/14698468

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-30
pubmed:abstractText
Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT(2A) and 5-HT(6)) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT(2A) receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT(6) receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
354
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Serotonergic genes and personality traits in the Korean population.
pubmed:affiliation
Yong-In Psychiatric Research Institute, Kyeonggi Province, 449-769, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't