Linked Life Data

14697327

Source:http://linkedlifedata.com/resource/pubmed/id/14697327

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-30
pubmed:abstractText
After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral nerve, the latter being dependent on tumor necrosis factor-alpha (TNF). Here we asked whether COX inhibitors attenuate pain behavior induced by chronic constrictive sciatic nerve injury (CCI) or intraneural injection of TNF (2.5 pg/ml). Rats received either 0.9% saline, the nonselective COX inhibitor ibuprofen (40 mg/kg) or the selective COX-2 inhibitor celecoxib (10 or 30 mg/kg) twice daily by gavage started 2 days before, 12 h or 7 days after surgery. Mechanical allodynia and thermal hyperalgesia induced by CCI was moderately, but consistently attenuated by early (day -2 or 12 h after CCI), but not late (7 days after CCI) ibuprofen and celecoxib treatment. Mechanical allodynia, but not thermal hyperalgesia induced by intraneural TNF, was reduced by ibuprofen, but not by celecoxib treatment 5 and 7 days after injection. Sciatic nerves, lumbar dorsal root ganglia (DRG) and spinal cords from rats with treatment started 12 h after surgery were analyzed for prostaglandin E2 (PGE2) levels 10 days after CCI. In injured nerves and ipsilateral DRG, PGE2 levels were increased. Ibuprofen treatment reversed PGE2 levels in injured nerves and DRG, whereas celecoxib blocked increased PGE2 levels only in nerves. In spinal cord, no change in PGE2 levels was observed. In contrast to the marked inhibition of nerve-injury-induced upregulation of PGE2 by COX inhibitors, the effect on pain behavior was modest. Nerve-injury- and TNF-induced pain-related behavior seem to be only partly dependent on peripheral prostaglandins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:14697327-Animals, pubmed-meshheading:14697327-Behavior, Animal, pubmed-meshheading:14697327-Cyclooxygenase 2, pubmed-meshheading:14697327-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:14697327-Cyclooxygenase Inhibitors, pubmed-meshheading:14697327-Dinoprostone, pubmed-meshheading:14697327-Disease Models, Animal, pubmed-meshheading:14697327-Ganglia, Spinal, pubmed-meshheading:14697327-Hyperalgesia, pubmed-meshheading:14697327-Ibuprofen, pubmed-meshheading:14697327-Isoenzymes, pubmed-meshheading:14697327-Pain Measurement, pubmed-meshheading:14697327-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:14697327-Pyrazoles, pubmed-meshheading:14697327-Rats, pubmed-meshheading:14697327-Rats, Sprague-Dawley, pubmed-meshheading:14697327-Sciatic Neuropathy, pubmed-meshheading:14697327-Spinal Cord, pubmed-meshheading:14697327-Sulfonamides, pubmed-meshheading:14697327-Tumor Necrosis Factor-alpha
pubmed:year
2004
pubmed:articleTitle
Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat.
pubmed:affiliation
Department of Neurology, University of Würzburg, 97080 Würzburg, Germany. schaefers_m@klinik.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't