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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-12-30
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pubmed:abstractText |
The mechanism by which oral glutamine (GLN) prevents 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer is unknown. While GLN triples the negative extraction of gut glutathione (GSH) in rats, DMBA significantly disrupts it. Actual gut GSH flux has not been reported. We hypothesized that the gut is a producer of GSH; DMBA blocks gut GSH production and supplemental oral GLN antagonizes this effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
242-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14697290-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:14697290-Administration, Oral,
pubmed-meshheading:14697290-Animal Nutritional Physiological Phenomena,
pubmed-meshheading:14697290-Animals,
pubmed-meshheading:14697290-Carcinogens,
pubmed-meshheading:14697290-Female,
pubmed-meshheading:14697290-Glutamine,
pubmed-meshheading:14697290-Glutathione,
pubmed-meshheading:14697290-Intestines,
pubmed-meshheading:14697290-Mammary Neoplasms, Animal,
pubmed-meshheading:14697290-Rats,
pubmed-meshheading:14697290-Rats, Sprague-Dawley
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pubmed:year |
2003
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pubmed:articleTitle |
Gut glutathione metabolism and changes with 7,12-DMBA and glutamine.
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pubmed:affiliation |
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
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pubmed:publicationType |
Journal Article
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