Linked Life Data

14696970

Source:http://linkedlifedata.com/resource/pubmed/id/14696970

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-4
pubmed:dateCreated
2003-12-30
pubmed:abstractText
The concept that adenosine triphosphate (ATP) can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission (Edwards et al., 1992), inflammation (Perregaux et al., 1994), apoptosis (Chow et al., 1997), and bone remodelling (Jones et al., 1997; Morrison et al., 1998) is now widely accepted. Since the early work of Burnstock (Burnstock, 1972), the number of characterized P2 receptors responsive to extracellular nucleotides has increased dramatically. It is now known that both osteoblasts and osteoclasts express multiple P2 receptor subtypes, and the increasing number of nucleotide-induced effects reported to occur in bone serves to highlight the importance of these receptors in the bone microenvironment and the bone remodeling processes. In this article we will review work from our laboratory, and others, that has established nucleotides and P2 receptors as important signaling molecules in bone. In particular, we will focus on the expression of P2 receptors by osteoclasts and, more specifically, the P2X7 receptor and its paradoxical role in osteoclast function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1045-4403
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-42
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation.
pubmed:affiliation
Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA. Alison.Gartland@umassmed.edu
pubmed:publicationType
Journal Article, Review