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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-12-30
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pubmed:abstractText |
The present study investigated whether Shenqi-wan possesses a protective effect against hydrogen peroxide (H2O2)-induced apoptosis of the hippocampal cell line HiB5. Through morphological and biochemical analyses, it was demonstrated that HiB5 cells treated with H2O2 exhibited several apoptotic features, while cells pre-treated with Shenqi-wan prior to H2O2 exposure showed a decrease in the occurrence of apoptosis. In addition, a patch clamp study revealed that Shenqi-wan inhibited profoundly N-methyl-D-aspartic acid (NMDA) receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results suggest that Shenqi-wan may exert its protective effect against H2O2-induced apoptosis via inhibition of NMDA receptors in hippocampal neuronal cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0192-415X
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pubmed:author |
pubmed-author:BahnGeon-HoGH,
pubmed-author:ChungSeok-HeeSH,
pubmed-author:JangMi-HyeonMH,
pubmed-author:KimChang-JuCJ,
pubmed-author:KimSung-SooSS,
pubmed-author:LeeJong-SooJS,
pubmed-author:PaikEun-KyungEK,
pubmed-author:ParkJae-HyungJH,
pubmed-author:ShinHyun-DaeHD,
pubmed-author:ShinHyun-TaegHT,
pubmed-author:ShinMin-ChulMC
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
675-86
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:14696671-Antioxidants,
pubmed-meshheading:14696671-Apoptosis,
pubmed-meshheading:14696671-Cell Cycle,
pubmed-meshheading:14696671-Cell Survival,
pubmed-meshheading:14696671-DNA Fragmentation,
pubmed-meshheading:14696671-Drugs, Chinese Herbal,
pubmed-meshheading:14696671-Flow Cytometry,
pubmed-meshheading:14696671-Hippocampus,
pubmed-meshheading:14696671-Humans,
pubmed-meshheading:14696671-Hydrogen Peroxide,
pubmed-meshheading:14696671-Neurons,
pubmed-meshheading:14696671-Plant Extracts,
pubmed-meshheading:14696671-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:14696671-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Protective effect of shenqi-wan against H2O2-induced apoptosis in hippocampal neuronal cells.
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pubmed:affiliation |
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine Kyung Hee University, Seoul, Korea.
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pubmed:publicationType |
Journal Article
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