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pubmed-article:14696401pubmed:abstractTextThe EDG-2 (endothelial cell differentiation gene-2) has been characterized as one of the high-affinity receptors of lysophosphatidic acid: an extracellular lipid mediator which can induce tumor progression. Recent studies have revealed that EDG-2 plays an important role in various pathological events including cell proliferation and tumor development. The investigation of EDG-2 is thus considered important for eliciting the mechanism of tumorigenesis. However, in colorectal tissue, the clinical significance of EDG-2 expression remains unclear. In the current study, we examined the immunohistochemical expression of EDG-2 in colorectal mucosa and adenoma, and clarified its relation with the clinicopathological features.lld:pubmed
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pubmed-article:14696401pubmed:articleTitleThe Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.lld:pubmed
pubmed-article:14696401pubmed:affiliationDepartment of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. komuro@kt.rim.or.jplld:pubmed
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